首页|A NEW N-cis-CQ UM ARO YLT YRAMINE DERIVATIVE FROM Fissistigma oldhamii
A NEW N-cis-CQ UM ARO YLT YRAMINE DERIVATIVE FROM Fissistigma oldhamii
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NSTL
A new N-cis-coumaroyltyramine derivative, fissistyramine (1), along with four known coumaroyltyramine derivatives (2-5), was isolated from the stems of Fissistigma oldhamii (Hemsl.) Merr. The structure of the new compound 1 was determined by ID and 2D NMR as well as by HR-ESI-MS. The inhibitory effect of all the compounds on the proliferation of primary synovial cells was evaluated. Compounds 1, 2, and 5 exhibited inhibitory activity on synoviocytes, with IC50 values of 12.1, 13.8, and 15.6 uM.
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University. 571158, Haikou, P. R. China
NSTL
