首页|Extra-synaptic modulation of GABA(A) and efficacy in bipolar disorder
Extra-synaptic modulation of GABA(A) and efficacy in bipolar disorder
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NSTL
Elsevier
Background: Bipolar disorder type I is a severe psychiatric condition that leads to significant morbidity and mortality and whose treatment remains suboptimal。 Its pathophysiology involves disturbance in the control of ionic fluxes so that when patients are either manic or depressed， the resting membrane potential of neurons is more depolarized than normal。 Available mood stabilizers have a shared mechanism of normalizing ion flux by compensating for ionic abnormalities， and normalizing membrane potential。
Extra synapticGABA(A) receptorsBipolar disorderBrexanoloneGanaxoloneGaboxadol
Ali, Ziad、El-Mallakh, Rif S.
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Univ Kentucky, Med Ctr Bowling Green, Dept Psychiat, Coll Med, Bowling Green, KY USA
NSTL
Elsevier
