首页|An unmodified boron-doped diamond electrode for electroanalytical investigation and sensitive voltammetric quantification of antiviral drug famciclovir in the pharmaceutical formulation and serum samples
An unmodified boron-doped diamond electrode for electroanalytical investigation and sensitive voltammetric quantification of antiviral drug famciclovir in the pharmaceutical formulation and serum samples
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NSTL
Elsevier
? 2022 Elsevier B.V.The current study offers an electroanalytical investigation and a novel voltammetric approach for the quantitative analysis of famciclovir (FCV) utilizing an unmodified boron-doped diamond (BDD) electrode. An irreversible, well-defined, diffusion-controlled anodic peak was observed at approximately +1.27 V (vs. Ag/AgCl) in acetate buffer solution (ABS, 0.1 mol L?1, pH 4.7) when the agent was tested using cyclic voltammetry. The voltammetric signals of the oxidation peaks are pH dependent (ranging from 2.0 to 7.0). Using square-wave mode, a good linear response was obtained for FCV quantification in 0.1 mol L?1 ABS (pH 4.7) solution at +1.26 V (vs. Ag/AgCl). Wide dynamic range was found for 0.1 to 50.0 μg mL?1 (3.11 × 10?7-1.56 × 10?4 mol L?1), with a low detection limit of 0.029 μg mL?1 (9.02 × 10?8 mol L?1). Applicability of the proposed method for the determination of FCV was demonstrated in the pharmaceutical formulation and model serum samples.
Drug analysisElectrochemical determinationPretreatmentSquare-wave voltammetry
Ali H.S.、Barzani H.A.H.、Yardim Y.
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Van Yuzuncu Yil University Faculty of Science Department of Analytical Chemistry
Van Yuzuncu Yil University Faculty of Pharmacy Department of Analytical Chemistry
NSTL
Elsevier
