Fitoterapia2022，Vol.1598.DOI:10.1016/j.fitote.2022.105200

Analysis of botanicals and botanical supplements by LC-MS/MS-based molecular networking: Approaches for annotating plant metabolites and authentication

Jouaneh, Terra Marie M. Motta, Neil Wu, Christine Coffey, Cole Via, Christopher W. Kirk, Riley D. Bertin, Matthew J.
Fitoterapia2022，Vol.1598.DOI:10.1016/j.fitote.2022.105200
✕
  • NSTL
  • Elsevier

Analysis of botanicals and botanical supplements by LC-MS/MS-based molecular networking: Approaches for annotating plant metabolites and authentication

Jouaneh, Terra Marie M. 1Motta, Neil 1Wu, Christine 1Coffey, Cole 1Via, Christopher W. 1Kirk, Riley D. 1Bertin, Matthew J.1
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作者信息

  • 1. Univ Rhode Isl
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Abstract

Prior to the advent of modern medicine, humans have used botanicals extensively for their therapeutic potential. With the majority of newly approved drugs having their origins in natural products, plants remain at the forefront of drug discovery. Continued research and discovery necessitate the use of high-throughput analytical methods to screen and identify bioactive components and potential therapeutic molecules from plants. Utilizing a pre-generated plant extract library, we subjected botanicals to LC-MS/MS-based molecular networking to determine their chemical composition and relatively quantify already known metabolites. The LC-MS/MS-based molecular networking approach was also used to authenticate the composition of dietary supplements against their corresponding plant specimens. The networking procedures provided concise visual representations of the chemical space and highly informative assessments of the botanicals. The procedures also proved to define the composition of the botanical supplements quickly and efficiently. This offered an innovative approach to metabolite profiling and authentication practices and additionally allowed for the identification of new, putatively unknown metabolites for future isolation and biological evaluation.

Key words

Echinacea/Black cohosh/Ashwagandha/Molecular networking/LC-MS/MS/MASS/ECHINACEA/PRODUCTS

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出版年

2022
Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
被引量5
参考文献量40
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