Drug development and industrial pharmacy2021，Vol.47Issue(12) ：8.DOI:10.1080/03639045.2022.2070760

Formulation and in vitro and in vivo evaluation of surfactant-stabilized mucoadhesive nanogels for vaginal delivery of fluconazole

Aleanizy, Fadilah Sfouq Taha, Ehab, I Salem-Bekhit, Mounir M. Felimban, Alaa M. J. Al-Suwayeh, Saleh A. Al-Joufi, Fakhria A. Muharram, Magdy M. Alqahtani, Fulwah Y. Shakeel, Faiyaz Youssof, Abdullah M. E. Bayomi, Mohsen Abouelela, Amal E. F.
Drug development and industrial pharmacy2021，Vol.47Issue(12) ：8.DOI:10.1080/03639045.2022.2070760
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  • NSTL
  • Taylor & Francis

Formulation and in vitro and in vivo evaluation of surfactant-stabilized mucoadhesive nanogels for vaginal delivery of fluconazole

Aleanizy, Fadilah Sfouq 1Taha, Ehab, I 1Salem-Bekhit, Mounir M. 1Felimban, Alaa M. J. 1Al-Suwayeh, Saleh A. 1Al-Joufi, Fakhria A. 2Muharram, Magdy M. 3Alqahtani, Fulwah Y. 1Shakeel, Faiyaz 1Youssof, Abdullah M. E. 1Bayomi, Mohsen 1Abouelela, Amal E. F.1
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作者信息

  • 1. Coll Pharm,King Saud Univ
  • 2. Coll Pharm,Jouf Univ
  • 3. Coll Pharm,Prince Sattam Bin Abdulaziz Univ
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Abstract

Surfactant-stabilized mucoadhesive nanogels (NGs) for vaginal delivery of fluconazole (FLZ) were studied and evaluated in this work. FLZ-NG formulations were prepared using two different types of mucoadhesive polymers, Carbopol 934 (Ca934) and Pluronic F-127 (PF127). A rheology study revealed a non-Newtonian pseudoplastic flow behavior (shear thinning) in the prepared NGs. The viscosity of Ca934 NG (0.47 Pa s) was much lower compared to the PF127 NG (6.10 Pa s). The rheology study results correlated well with the in vitro FLZ release profile from the NG formulations. A pH study (pH = 3.90-4.90) revealed that the formulations were physiologically suitable for vaginal application, to avoid the irritation of the vaginal mucosa. Finally, in vitro and in vivo antimicrobial tests were performed. FLZ incorporated into the Ca934 gel had the strongest antimicrobial effect, with a mean inhibition zone of 24 +/- 1.6 mm. Based on these results, it was concluded that the mucoadhesive NG incorporating FLZ resulted in a sustained release and enhanced antimicrobial effect, which would enhance and prolong the therapeutic effects of vaginally delivered FLZ.

Key words

Antifungal activity/Carbopol 934/fluconazole/mucoadhesive nanogel/Pluronic F-127/ANTIFUNGAL AGENT/GEL/CANDIDIASIS/POLOXAMER/F127

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出版年

2021
Drug development and industrial pharmacy

Drug development and industrial pharmacy

SCI
ISSN：0363-9045
被引量2
参考文献量55
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