首页|Hydrogels formed by crosslinked poly(vinyl alcohol) as sustained drug delivery systems.
Hydrogels formed by crosslinked poly(vinyl alcohol) as sustained drug delivery systems.
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NSTL
Poly(vinyl alcohol) was crosslinked with ethylene glycol diglycidyl ether to obtain hydrogel-forming polymers. The polymers were also substituted with oleoyl chloride, providing hydrogels with weak solubility. These new polymeric materials were evaluated for the formulation of sustained drug delivery systems. Vancomycin hydrochloride was used as a peptidic model drug whose sustained release should minimize its inactivation in the upper part of the gastrointestinal tract. Spray-dried mixtures of the drug and the polymer [at 1:4 and 1:8 (w:w) ratios] were prepared and the release of the drugs from the mixtures was evaluated in vitro at pH 2.0, 5.5, 7.4, and 8.0. The results indicated that the crosslinked polymers slowed down the release of the drugs with respect to the pure drug at each pH. The degree of crosslinking of ethylene glycol diglycidyl ether and the extent of substitution with oleoyl chloride were found to influence drug release.
HydrogelsPolyvinyl Alcohol水凝胶类聚乙烯乙醇
Orienti I、Trere R、Luppi B、Bigucci F、Cerchiara T、Zuccari G、Zecchi V
展开 >
Department of Pharmaceutical Sciences, Bologna University, Via S. Donato 19/2, 40127 Bologna, Italy. orienti@biocfarm.unibo.it
NSTL
