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Our contributions to applications of mesoporous silica nanoparticles

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  • NSTL
  • Elsevier
Our contributions to mesoporous silica materials in the field of biomedicine are reported in this article. This perspective article represents our work in the basics of the material, preparing different ranges of mesoporous silica nanoparticles with different diameters and with varied pore sizes. We demonstrated the high loading capacity of these materials. Additionally, the possibility of functionalizing both internal and external surface with different organic or inorganic moieties allowed the development of stimuli responsive features which allowed a proper control on the administered dose. In addition, we have demonstrated that these carriers are not toxic, and we have also ensured that the load reaches its destination without affecting healthy tissues. Statement of significance This paper presents my personal opinion and background on a hot topic as mesoporous silica nanoparticles for drug delivery. To this aim it provides a comprehensive and historical overview on the innovative contributions of my research group to this rapidly expanding field of research. (c) 2021 The Author. Published by Elsevier Ltd on behalf of Acta Materialia Inc. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

Mesoporous silica materialsNanoparticlesDrug deliveryControlled releaseFunctionalizationStimuli-responsiveTargetingBiocompatibilityBiomedicineMESENCHYMAL STEM-CELLSDRUG-DELIVERYCONTROLLED-RELEASEULTRASOUNDMCM-41BIOCOMPATIBILITYNANOCARRIERSPENETRATIONTHERAPYPROTEIN

Vallet-Regi, Maria

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Sch Pharm,Univ Complutense Madrid

2022

10.1016/j.actbio.2021.10.011

Acta biomaterialia

Acta biomaterialia

EISCI
ISSN：1742-7061
年,卷(期)：2022.137
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