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Recent advances in biosensor for DNA glycosylase activity detection

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  • NSTL
  • Elsevier
Base excision repair (BER) is vital for maintaining the integrity of the genome under oxidative damage. DNA glycosylase initiates the BER pathway recognizes and excises the mismatched substrate base leading to the apurinic/apyrimidinic site generation, and simultaneously breaks the single-strand DNA. As the aberrant activity of DNA glycosylase is associated with numerous diseases, including cancer, immunodeficiency, and atherosclerosis, the detection of DNA glycosylase is significant from bench to bedside. In this review, we summarized novel DNA strategies in the past five years for DNA glycosylase activity detection, which are classified into fluorescence, colorimetric, electrochemical strategies, etc. We also highlight the current limitations and look into the future of DNA glycosylase activity monitoring.

DNA glycosylaseBiosensorDetectionInhibitorAmplificationROLLING CIRCLE AMPLIFICATIONHIGHLY SENSITIVE DETECTIONHOST-GUEST RECOGNITIONLABEL-FREESIGNAL AMPLIFICATIONULTRASENSITIVE DETECTIONELECTROCHEMICAL ASSAYCOPPER NANOCLUSTERSURACILSTRATEGY

Ouyang, Yuzhen、Liu, Yifan、Deng, Yuan、He, Hailun、Huang, Jin、Ma, Changbei、Wang, Kemin

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Cent South Univ

Hunan Univ

2022

10.1016/j.talanta.2021.123144

Talanta

Talanta

EISCI
ISSN：0039-9140
年,卷(期)：2022.239
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