Highly efficient disinfection based on multiple enzyme-like activities of Cu3P nanoparticles: A catalytic approach to impede antibiotic resistance

Chao, Daiyong ¹Dong, Qing ¹Chen, Jinxing ²Yu, Zhixuan ²Wu, Weiwei ²Fang, Youxing ²Liu, Ling ²Dong, Shaojun¹

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作者信息

1. Jilin Univ
2. Chinese Acad Sci
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Abstract

Cu3P nanoparticles (NPs) were proposed as an efficient antibacterial agent for impeding bacterial resistance. Both sensitive and resistant strains of E. coli and S. aureus (3 x 106 CFU mL-1), and the microbial populations from a fishery water were completely inactivated by Cu3P NPs (<= 1.5 mu g mL-1) within 30 min with no regrowth. The antibacterial mechanism of Cu3P NPs relied on their own multiple enzyme-like activities, to elucidate, the action of ROS produced by their oxidase- and peroxidase- like activities was facilitated by their inherent activities for glutathione depletion and the lipid peroxidation. Comparing with that traditional antibiotics induced bacterial resistance (6 out of 7) within 3 passages, Cu3P NPs kept their initially inactivated efficiency, demonstrating that they can delay the onset of bacterial resistance. Furthermore, the Cu3P NPs shown no obviously toxic effect on aquatic organisms and a negligible side-effect toward mammalian tissues. This strategy is insightful for struggle with resistant bacteria.

Key words

Cu 3 P NPs/Super antibacterial efficiency/Bacterial resistance/Fishery disinfection/Wound healing/WATER DISINFECTION/ANTIBACTERIAL/INACTIVATION/MECHANISMS/EVOLUTION/HYDROGEN/OXIDASE/G-C3N4

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出版年

2022

Applied Catalysis

ISSN：0926-3373

被引量20

参考文献量58

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