首页|Molecular biological mechanism of action in cancer therapies: Juglone and its derivatives, the future of development
Molecular biological mechanism of action in cancer therapies: Juglone and its derivatives, the future of development
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NSTL
Juglone (5 - hydroxy -1，4- naphthalene diketone) is a kind of natural naphthoquinone， present in the roots， leaves， nut-hulls， bark and wood of walnut trees。 Recent studies have found that Juglone has special significance in the treatment of cancer， which plays a significant role in the resistance of cancer cell proliferation， induction of cancer cell apoptosis， induction of autophagy， anti-angiogenesis and inhibition of cancer cell migration and invasion， etc。 Additionally， its derivatives also play a tumor suppressive effect。 In conclusion， Juglone and its derivatives have been identified as effective anticancer drugs。 This paper reviews action mechanisms of Juglone and its derivatives in cancer treatment。
NSTL
