首页|α-Boryl Isocyanides Enable Facile Preparation of Bioactive Boropeptides
α-Boryl Isocyanides Enable Facile Preparation of Bioactive Boropeptides
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NSTL
Wiley
Boronic acids and their derivatives have found utility as synthetic building blocks, chemosensors, and as biologically active targets of synthesis. Both the biological activity and chemical reactivity of boronic acids stem from boron's Lewis acidity. While useful in a broad range of applications, boron's propensity to undergo reactions with Lewis bases becomes problematic for functional-group compatibility during synthesis. Reagents that streamlineinstallation of a carbon-boron bond in ste reochemically complex, heteroatom-rich environments, are expected to find application not only as starting materials but also as late-stage precursors to the endpoints of synthesis. In regards to the latter, the borylamide motif (Figure 1), found in the struc- tures of biologically active boropeptides, is of particular significance.
NSTL
Wiley
