Abstract
? 2022 Elsevier LtdSix undescribed isoquinolines, including one rarely reported N-benzyl isoquinoline together with sixteen known ones were isolated from C. tomentella. Their planar structures and absolute configurations were elucidated by extensive analyses of UV, IR, NMR, HRESIMS, DP4+ probability analysis as well as ECD calculations. Biological evaluations revealed that 3,4-2H-tomentelline C (6) showed significant cytotoxicity (IC50 = 7.42 μM) against the HepG2 cell line while (1′R, 2′S)-coptichine B (3) exhibited stronger antibacterial activities.
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Elsevier