首页|Phorneroids A-M, diverse types of diterpenoids from Euphorbia neriifolia
Phorneroids A-M, diverse types of diterpenoids from Euphorbia neriifolia
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NSTL
Elsevier
A chemical investigation on the aerial parts of Euphorbia neriifolia led to the identification of thirteen undescribed diterpenoids, phorneroids A-M, including ent-abietane (A-D), ent-kaurane (E-G), ent-atisane (H-K), and ent- isopimarane (L and M) types, together with three known compounds. Phorneroid A represents the first example of 8-spiro-fused 9,10-seco-ent-abietane diterpenoid lactone featuring a unique 6/5/6/5 spirocyclic framework. Biological assays showed that some of the compounds displayed moderate cytotoxicity against two human tumor cell lines, A549 and HL-60.
Euphorbia neriifoliaEuphorbiaceaeDiterpenoidEnt-abietaneEnt-kauraneEnt-atisaneEnt-isopimaranePhorneroids A-MCytotoxicitySTEM BARKLACTONESPLANTSROOTS
NSTL
Elsevier
