A chemical investigation on the aerial parts of Euphorbia neriifolia led to the identification of thirteen undescribed diterpenoids, phorneroids A-M, including ent-abietane (A-D), ent-kaurane (E-G), ent-atisane (H-K), and ent- isopimarane (L and M) types, together with three known compounds. Phorneroid A represents the first example of 8-spiro-fused 9,10-seco-ent-abietane diterpenoid lactone featuring a unique 6/5/6/5 spirocyclic framework. Biological assays showed that some of the compounds displayed moderate cytotoxicity against two human tumor cell lines, A549 and HL-60.
Key words
Euphorbia neriifolia/Euphorbiaceae/Diterpenoid/Ent-abietane/Ent-kaurane/Ent-atisane/Ent-isopimarane/Phorneroids A-M/Cytotoxicity/STEM BARK/LACTONES/PLANTS/ROOTS
NSTL
Elsevier