首页|Outcome Measures to Assess Dry Eye Severity: A Review

Outcome Measures to Assess Dry Eye Severity: A Review

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  • NSTL
  • Taylor & Francis
Outcome measures used to assess efficacy of dry eye therapeutics have not been consistently applied in clinical settings, nor have they been shown to correlate with functional outcomes. We propose that corneal staining, a clinically meaningful dry eye parameter, should be used as a standard objective outcome measure across all clinical trials evaluating dry eye treatments. We justify this based on evidence regarding its relationship to vision and vision related quality-of-life. In addition, corneal staining has been shown to correlate with ocular surface inflammation, a well elucidated aspect of dry eye pathophysiology and an active area in therapeutics research. No one outcome measure explored herein correlates perfectly to this heterogenous disease. However, there is mounting evidence showing the correlation between corneal staining and functional visual indices. We hope that future clinical trials will standardize corneal staining as a measure to determine the efficacy of interventions and justify their clinical utility.

Dry eyeoutcome measureocular inflammationfunctional visual acuityocular therapeuticscorneal stainingOPHTHALMIC SOLUTION 5.0-PERCENTOCULAR SURFACE DISEASETEAR FILM STABILITYRED THREAD TESTCLINICAL-TRIALSROSE-BENGALINFLAMMATORY CYTOKINESCONTRAST SENSITIVITYLISSAMINE GREENVISUAL-ACUITY

Hirabayashi, Kyle J.、Akpek, Esen K.、Ahmad, Sumayya

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New York Eye & Ear Infirm Mt Sinai,Icahn Sch Med Mt Sinai

Sch Med,Johns Hopkins Univ

2022

10.1080/09273948.2022.2027461

Ocular immunology and inflammation

Ocular immunology and inflammation

SCI
ISSN：0927-3948
年,卷(期)：2022.30(2)
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