Fitoterapia2022，Vol.1598.DOI:10.1016/j.fitote.2022.105175

Structurally diverse isoquinoline and amide alkaloids with dopamine D2 receptor antagonism from Corydalis bungeana

Han, Yang Hou, Tao Zhang, Zi-Hui Wang, Yao-Dong Cheng, Jun-Xiang Zhou, Han Wang, Ji-Xia Feng, Jia-Tao Liu, Yan-Fang Guo, Zhi-Mou Liang, Xin-Miao
Fitoterapia2022，Vol.1598.DOI:10.1016/j.fitote.2022.105175
✕
  • NSTL
  • Elsevier

Structurally diverse isoquinoline and amide alkaloids with dopamine D2 receptor antagonism from Corydalis bungeana

Han, Yang 1Hou, Tao 1Zhang, Zi-Hui 2Wang, Yao-Dong 1Cheng, Jun-Xiang 3Zhou, Han 1Wang, Ji-Xia 1Feng, Jia-Tao 1Liu, Yan-Fang 1Guo, Zhi-Mou 1Liang, Xin-Miao1
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作者信息

  • 1. Chinese Acad Sci
  • 2. Dalian Polytech Univ
  • 3. DICP CMC Innovat Inst Med
  • 折叠

Abstract

Four new isoquinoline alkaloids including a benzophenanthridine alkaloid (1), a morphine derivative (2), a narceine-type alkaloid (3) and a simple isoquinoline alkaloid (4), a new amide alkaloid (5) and a new phthalic acid derivative (6), together with eleven known alkaloids (7-17) were obtained from the whole herbs extract of Corydalis bungeana Turcz. Their structures and absolute configurations were elucidated by extensive spectroscopic data analysis including HRESIMS, NMR and electronic circular dichroism (ECD) and ECD calculation. Compounds 1-17 were evaluated for dopamine D2 receptor activity in CHO-D2 cells. Among them, 16 showed the highest antagonistic activity on the D2 receptor with an IC50 value of 2.04 +/- 0.01 mu M. Compounds 14 and 15 exhibited moderate antagonism with IC50 values of 13.66 +/- 2.28 and 31.72 +/- 2.52 mu M, respectively.

Key words

Corydalis bungeana/Papaveraceae/Isoquinoline alkaloids/Amide alkaloid/D2 receptor activity/RAT PLASMA/TURCZ./CHROMATOGRAPHY/COMPONENTS

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出版年

2022
Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
被引量3
参考文献量33
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