The development of mild and efficient strategies for the construction of carbon-heteroatom bonds remains one of the most important goals in organic chemistry, with particular interest in methods for aromatic C-O bond formation. Currently, transition-metal-catalysed Ullmann-type chemistry is one of the most popular methods for the construction of C-O bonds1. The traditional catalytic cycle for the transition-metal-catalysed synthesis of phenols involves three fundamental steps: oxidative addition, ligand metathesis and reductive elimination (Fig. la, left). The oxygen source in these reactions is usually H2O or a protic oxygen-based nucleophile in combination with a base.
Jun-Jie Chen、Huan-Ming Huang
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School of Physical Science and Technology, ShanghaiTech University, Shanghai, China
NSTL
