首页|Abieshanesides A and B, two unique ent-18,19-dinoricetexane diterpenoid glycosides from Abies beshanzuensis M.H. Wu

Abieshanesides A and B, two unique ent-18,19-dinoricetexane diterpenoid glycosides from Abies beshanzuensis M.H. Wu

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  • NSTL
  • Elsevier
? 2021 Elsevier B.V.Two unprecedented ent-18,19-dinoricetexane diterpenoid glycosides, named abieshanesides A (1) and B (2), together with seven known compounds, have been isolated from the dead trunks and branches of Abies beshanzuensis M.H. Wu. To our knowledge, abieshanesides A and B represent the first ent-18,19-dinoricetexane diterpenoid glycosides found in natural sources. Their structures and absolute configurations were elucidated by using a combination of spectroscopic techniques and comparison of experimental and calculated electronic circular dichroism (ECD) data. The MTT experiments showed that (E)-resveratrol (7) could inhibit viability of MH7A cells with the IC50 value of 12.5 μM. Compound 7 was able to block MH7A cell proliferation and was associated with G0/G1-phase cell cycle arrest. Flow cytometric analysis showed that the treatment by 7 significantly induced the proliferation of MH7A cells in a dose-dependent manner.

Abies beshanzuensisAbietaneAnti-proliferation activityEnt-1819-dinoricetexaneStructural elucidation

Xu J.-B.、Xie X.-Y.、Zhou Q.-Q.、Zhu J.-Y.

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Department of Pharmacy College of Medicine Jiaxing University

Clinical Laboratory Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine

2022

10.1016/j.fitote.2021.105096

Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
年,卷(期)：2022.156
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