首页|The biological activities of butyrylcholinesterase inhibitors
The biological activities of butyrylcholinesterase inhibitors
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Acetylcholinesterase (AChE) inhibitor is the first choice for the treatment of Alzheimer's disease (AD), but it has some defects, such as dose limitation and unsatisfactory long-term treatment effect. Recent studies have shown that butyrylcholinesterase (BuChE) inhibitors or double acetyl and butyryl cholinesterase inhibitors have better curative effects on AD, and the side effects are lower than those of specific AChE inhibitors. Dual target cholinesterase inhibitors have become a new hotspot in the research of anti-AD drugs. Herein, the synthesis and bioactivities of BuChE inhibitors were reviewed.
ButylcholinesteraseSynthesisBioactivities
Shiyang Zhou、Gangliang Huang
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Laboratory of Carbohydrate Science and Engineering, Chongqing Normal University, Chongqing 401331
NSTL
