Ketogenic diet as a potential intervention for lipedema

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NSTL
Elsevier

外文摘要：Lipedema (LI) is a common yet misdiagnosed condition， often misconstrued with obesity。 LI affects women almost exclusively， and its painful and life-changing symptoms have long been thought to be resistant to the lifestyle interventions such as diet and exercise。 In this paper， we discuss possible mechanisms by which patients adopting a ketogenic diet (KD) can alleviate many of the unwanted clinical features of LI。 This paper is also an effort to provide evidence for the hypothesis of the potency of this dietary intervention for addressing the symptoms of LI。 Specifically， we examine the scientific evidence of effectiveness of adopting a KD by patients to alleviate clinical features associated with LI， including excessive and disproportionate lower body adipose tissue (AT) deposition， pain， and reduction in quality of life (QoL)。 We also explore several clinical features of LI currently under debate， including the potential existence and nature of edema， metabolic and hormonal dysfunction， inflammation， and fibrosis。 The effectiveness of a KD on addressing clinical features of LI has been demonstrated in human studies， and shows promise as an intervention for LI。 We hope this paper leads to an improved understanding of optimal nutritional management for patients with LI and stimulates future research in this area of study。

外文关键词：

LipedemaKetogenic dietObesityLymphKetosisHypothyroid

作者：

Keith, L.、Seo, C. A.、Rowsemitt, C.、Pfeffer, M.、Wahi, M.、Staggs, M.、Dudek, J.、Gower, B.、Carmody, M.

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作者单位：

Lipedema Project, 60 Boston Ave, Boston, MA 02144 USA

Lipedema Simplified, Boston, MA USA

DethWench Profess Serv, Boston, MA USA

Lipedema Project Med Advisory Board, Boston, MA USA

Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA

Harvard Med Sch, Boston, MA 02115 USA

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出版年：

2021

DOI：

10.1016/j.mehy.2020.110435

Medical hypotheses

SCI

ISSN：0306-9877

年,卷(期)：2021.146

被引量5
参考文献量146