Regulatory role of adrenergic neurotransmitters on the spontaneous muscular activity in the ruminant trematode Paramphistomum cervi (Paramphistomatidae)

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NSTL
Cambridge Univ Press

外文摘要：The neuromuscular system of helminths is an important area for target identification and drug development. Many anthelmintics, namely ivermectin, levamisole, piperazine, pyrantel, praziquantel and organophosphates, produce paralysis of helminths by affecting their neuromuscular systems. The neuromuscular system of helminths is also an important area of research to identify some of the important differences between the neuromuscular physiology of helminths and mammals. The identification of differences would help in developing newer target-specific, safe and effective anthelmintics. The present study was carried out to investigate the effects of different adrenergic neurotransmitters (epinephrine, norepinephrine, dopamine, L-dopa) and their antagonists (propranolol and haloperidol) on the spontaneous muscular activity of isometrically mounted Paramphistomum cervi

外文关键词：

Biochemistry & Molecular BiologyParasitologyPhysiology

作者：

Verma, P. K.、Saikia, B.、Barua, C. C.、Hazarika, S.、Lahon, L. C.、Saikia, D.、Borah, R. S.

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作者单位：

Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, SKAUST, R.S. Pura, Jammu, India

Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati 781022, India

Department of Animal Biotechnology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati 781022, India

Department of Livestock Production and Management, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati 781022, India

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出版年：

2014

DOI：

10.1017/S0022149X13000266

Journal of Helminthology

SCI

ISSN：0022-149X

年,卷(期)：2014.88(3)

被引量1
参考文献量24