首页|Palmitoylethanolamide (PEA) reduces postoperative adhesions after experimental strabismus surgery in rabbits by suppressing canonical and non-canonical TGF beta signaling through PPAR alpha

Palmitoylethanolamide (PEA) reduces postoperative adhesions after experimental strabismus surgery in rabbits by suppressing canonical and non-canonical TGF beta signaling through PPAR alpha

扫码查看
原文链接
  • NSTL
  • Elsevier
Postoperative adhesions and scarring are the particular complication after strabismus surgery, for which there is currently no comprehensive treatment available. Preventing inflammation and fibrosis in the extraocular muscle are crucial for treatment of postoperative adhesions. In the present study, we found that administration of palmitoylethanolamide (PEA) attenuated postoperative inflammation and fibroproliferation through activating peroxisome proliferator-activated receptor alpha (PPAR alpha), thus prevented scar formation. Inhibition of PEA degradation by N-Acylethanolamine acid amidase (NAAA) inhibitor F96 led to the same pharmacological results. PPAR alpha activation suppressed both canonical and non-canonical TGF beta signaling. Mechanistically, we found that PPAR alpha directly bound to TGF beta-activated kinase 1 (TAK1), thus preventing its hyperphosphorylation and the activation of downstream p38 and JNK1/2 signaling. Taken together, current study suggested that PEA could be a novel therapeutic approach for postoperative adhesions after strabismus surgery.

StrabismusAdhesionsPalmitoylethanolamide (PEA)peroxisome proliferator-activated receptor alpha (PPAR alpha)TGE beta-activated kinase 1 (TAK1)

Li, Yitian、Zhao, Sichen、Xu, Sennan、Li, Yuhang、Wang, Chaowei、Ren, Jie、Li, Fei、Hu, Xiaokun、Lin, Kuantian、Qiu, Yan、Xiu, Yanghui

展开 >

Xiamen Univ, Affiliated Xiamen Eye Ctr, Xiamen 361005, Peoples R China

Xiamen Univ, Sch Med, Fujian Prov Key Lab Ophthalmol & Visual Sci, Eye Inst, Xiamen 361005, Peoples

Chinese Acad Sci, Xiamen Inst Rare Earth Mat, Haixi Inst, Xiamen 361005, Peoples R China

Fujian Med Univ, Zhangzhou Affiliated Hosp, Zhangzhou 363000, Peoples R China

Ningde Eye Hosp, Ningde 352100, Peoples R China

展开 >

2021

10.1016/j.bcp.2020.114398

Biochemical Pharmacology

Biochemical Pharmacology

ISTP
ISSN：0006-2952
年,卷(期)：2021.184
  • 2
  • 36