首页|Indium complexes of chlorin e(6 )trimethyl ester and methylpyropheophorbide a: Synthesis and photophysical characterization
Indium complexes of chlorin e(6 )trimethyl ester and methylpyropheophorbide a: Synthesis and photophysical characterization
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NSTL
Elsevier
Complexes of chlorin e6 trimethyl ester (H(2)Chl-e(6),), methylpyropheophorbide a (H2MePyroPheo) with indium (III) (InChl-e(6), and InMePyroPheo) were obtained from the corresponding macrocyclic ligands by complexation reaction with InIII trisacetylacetonate in acetic acid. In the case of methylpheophorbide a (H2MePheo) the complexation reaction is accompanied by side-process of exo-cyclic ring oxidation leading to inseparable mixture of InMePheo, its 13(2)-hydroxy derivative and InMePyroPheo. Spectral-luminescence and photophysical properties of H(2)Chl-e(6) and H(2)MePyroPheo and their In-III complexes were studied in DMF. Metal free chlorins have relatively long fluorescence lifetimes ((sic)(f) 5.4-7.5 ns) and moderate fluorescence and singlet oxygen quantum yields (Phi(F) ~& nbsp;0.39 and 0.29, Phi(delta & nbsp;)~& nbsp;0.47 and 0.60, for H(2)Chl-e(6) and H(2)MePyroPheo, respectively). It was revealed that insertion of the indium atom into the macrocyclic core strongly diminishes the fluorescence lifetimes ((sic)(f) 0.5-0.9 ns) and quantum yields (Phi(F) ~& nbsp;0.04-0.06), but facilitates the conversion to the triplet state leading to enhanced singlet oxygen quantum yields. Therefore, InChl-e(6) and InMePyroPheo having intense Q-band absorption in the therapeutic window (638 and 661 nm) and high values of Phi(delta) (0.84 and 0.76) can be considered as promising photosensitizers for PDT.
NSTL
Elsevier
