Tetrahedron letters2022，Vol.884.DOI:10.1016/j.tetlet.2021.153590

Total synthesis of remdesivir

Palli, Kishore Kumar Ghosh, Palash Avula, Shiva Krishna Rao, B. Sridhara Shanmukha Patil, Amol D. Ghosh, Subhash Sudhakar, Gangarajula Reddy, Chada Raji Mainkar, Prathama S. Chandrasekhar, Srivari
Tetrahedron letters2022，Vol.884.DOI:10.1016/j.tetlet.2021.153590
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  • NSTL
  • Elsevier

Total synthesis of remdesivir

Palli, Kishore Kumar 1Ghosh, Palash 1Avula, Shiva Krishna 1Rao, B. Sridhara Shanmukha 1Patil, Amol D. 1Ghosh, Subhash 1Sudhakar, Gangarajula 1Reddy, Chada Raji 1Mainkar, Prathama S. 1Chandrasekhar, Srivari1
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作者信息

  • 1. CSIR Indian Inst Chem Technol CSIR IICT
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Abstract

Remdesivir, the first drug approved by the FDA to treat COVID-19, is in high demand for patients infected with the SARS-CoV-2 virus. Herein, we report a facile approach minimizing the protecting group manipulations to afford remdesivir in good overall yield. (c) 2021 Elsevier Ltd. All rights reserved.

Key words

Remdesivir/Nucleotide/Nucleoside/COVID-19/RdRp/PRACTICAL SYNTHESIS/GS-5734/EBOLA

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出版年

2022
Tetrahedron letters

Tetrahedron letters

CCR
ISSN：0040-4039
被引量3
参考文献量38
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