首页|Structurally diverse Monascus pigments with hypolipidemic and hepatoprotective activities from highland barley Monascus
Structurally diverse Monascus pigments with hypolipidemic and hepatoprotective activities from highland barley Monascus
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NSTL
Elsevier
? 2021 Elsevier B.V.Highland barley Monascus has historically been used in solid state fermentation and traditional fermented foods in Tibet. It is possessed of the characteristics of medicine and food. Three new 8,13-unsaturated benzocyclodiketone-conjugated Monascus pigments (1–3), three new benzofuran Monascus pigments (4–6), three new butylated malonyl Monascus pigments (7–9), and eleven known Monascus pigment derivatives (10?20) were isolated from highland barley Monascus for the first time. Their structures were determined by analyzing NMR, MS, UV, and IR spectral data and compared with relevant references. Among them, compounds 2, 4, 6 showed important inhibition of pancreatic lipase activity, and decreased significantly FFA-induced lipid accumulation in HepG2 liver cells. Additionally, compounds 1, 10, 14, 16, 18 exhibited certain hepatoprotective activities against the damage in acetaminophen-induced HepG2 cells. The plausible biogenetic pathway and preliminary structure activity relationship of the selected compounds were scientifically summarized and discussed in this work.
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine Key Laboratory of Modern Preparation of Chinese Medicine of Ministry of Education Jiangxi University of Traditional Chinese Medicine
College of Chemistry and Pharmaceutical Engineering Nanyang Normal University
College of Chemistry and Pharmaceutical Engineering Huanghuai University
NSTL
Elsevier
