首页|e-Polylysine-coated liposomes loaded with a 8-CD inclusion complex loaded with carvacrol: Preparation, characterization, and antibacterial activities
e-Polylysine-coated liposomes loaded with a 8-CD inclusion complex loaded with carvacrol: Preparation, characterization, and antibacterial activities
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NSTL
Elsevier
In this study, carvacrol (Car) is first embedded in 8-cyclodextrin (8-CD) by the freeze-drying method to form the 8-cyclodextrin-Carvacrol inclusion compound (8-CD-Car), and then 8-CD-Car liposomes (8-CD-Car-Lip) and 8-CDCar liposomes coated with e-polylysine (e-PL/8-CD-Car-Lip) with different concentrations (0-20 mg/mL) of 8-CDCar were prepared. The liposomes were characterized, and their physicochemical properties, in vitro release characteristics, and antibacterial activities were analyzed. Results showed that the fabricated liposomes 8-CDCar-Lip and e-PL/8-CD-Car-Lip were nanosized and spherical, and the latter had a larger particle size (152.21 +/- 14.48 to 520.45 +/- 30.69 nm) and greater encapsulation efficiency (69.23 +/- 0.95 to 73.25 +/- 0.65%). The in vitro release study results showed that the rate of release from e-PL-coated liposomes was much lower than that from uncoated liposomes. Inhibition of bacterial growth experiments revealed that the minimum inhibitory concentration of e-PL/8-CD-Car-Lip against Escherichia coli and Staphylococcus aureus (0.025 and 0.05 mg/mL, respectively) was twice as low as that of 8-CD-Car-Lip and nearly 12 times lower than that of Car at the same concentration. The e-polylysine coating increased the diameter, encapsulation efficiency (EE), release time, and antibacterial activity of 8-CD-Car-Lip, and the fabricated complex liposome could be applicable as an additive in the design of antibacterial packaging.
NSTL
Elsevier
