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Minimal effective dose of mifepristone for medical abortion
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NSTL
The aim of this study is to compare the effectiveness of 100mg versus 200mg mifepristone along with misoprostol for medical abortion in gestation upto 56 days. This is a prospective controlled study. Eighty women seeking medical abortion with a gestation upto 56 days were included in the study. The women were randomly allotted into two groups. They received 100mg/200mg mifepristone on day 1 followed by 800mcg misoprostol two days later. Women who had not aborted completely by day 14, received a repeat dose of 400mcg misoprostol and were evaluated on day 21 for completeness of the procedure. Five women in both the groups had incomplete abortion by day 14 (12.5%), while one woman in the test group had to undergo dilatation and evacuation on day 3 due to excessive bleeding. By repeating a second dose of misoprostol, all of them aborted completely and the complete abortion rates were markedly improved from 85% and 87.5% in the test and the control group, respectively to 97.5% and 100%, respectively. It may be concluded that 100mg mifepristone is as effective as 200mg and appears to be the lowest effective dose for medical abortion.
NSTL
