首页|The Cortico-basal-cerebellar Neurocircuit is Linked to Personality Trait of Novelty Seeking

The Cortico-basal-cerebellar Neurocircuit is Linked to Personality Trait of Novelty Seeking

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  • NSTL
  • Elsevier
neuroimaging studies have highlighted the role of the prefrontal-subcortical circuits in personality trait of novelty seeking (NS), thought to be mediated by the dopaminergic system. However, it remains largely unknown whether cortico-basal-cerebellar connections, heavily influenced by dopamine, are implicated in this temperament dimension as well. The present study aimed to further investigate the relationship between the NS trait and the cortico-basal-cerebellar pathways by using structural covariance network analysis. Ninetyfive healthy female volunteers were included in this work, and NS was assessed with the Temperament and Character Inventory (TCI). Our results showed that NS scores were associated with structural connections between the cerebellum and the cerebral cortex, thalamus, and basal ganglia, substantiating the implication of the corticobasal-cerebellar circuits in the NS construct. In addition, structural connections between visual and sensorimotor regions were also associated with NS scores, indicating that sensory and motor information processing may contribute to NS-related behaviors. Overall, the current findings may deepen our understanding of brain structural circuits related to this temperament dimension. (c) 2022 IBRO. Published by Elsevier Ltd. All rights reserved.

novelty seekingcortico-basal-cerebellar connectionsstructural covariance networktemperament and character in-ventoryINDIVIDUAL-DIFFERENCESSTRUCTURAL COVARIANCEHARM AVOIDANCESENSATION SEEKINGCONNECTIVITYNETWORKSTEMPERAMENTTHICKNESSREWARDORGANIZATION

Wei, Luqing、Weng, Tingting、Dong, Hui、Baeken, Chris、Jiang, Ting、Wu, Guo-Rong

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Sch Psychol,Jiangxi Normal Univ

Fac Psychol,Southwest Univ

Fac Med & Hlth Sci,Univ Ghent

2022

10.1016/j.neuroscience.2022.02.027

Neuroscience

Neuroscience

SCI
ISSN：0306-4522
年,卷(期)：2022.488
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