首页|A new fast-responding fluorimetric"turn-on"sensor based on benzothiazole-phenanthridine for the sensitive,selective,and reversible detection of Cu~(2+)in real water samples and its use in bio-imaging
A new fast-responding fluorimetric"turn-on"sensor based on benzothiazole-phenanthridine for the sensitive,selective,and reversible detection of Cu~(2+)in real water samples and its use in bio-imaging
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This article describes a new chemosensor,2-(benzo[d]thiazol-2-yl)-6-(7,8,13,14-tetrahydrodibenzo[a,i] phenanthridin-5-yl)phenol(BTPP),which is based on the combination of phenanthridine and benzothiazole groups for the sensitive and selective detection of Cu~(2+).Following the successful synthesis of BTPP in a single step,the molecular structure of BTPP was verified by NMR,~(13)C NMR,mass spectrometry,and X-ray single-crystal analysis.These sensors exhibit high optical selectivity for the Cu~(2+)ion across a broad spectrum of other common metal ions in ACN/H2O(1:1)solution,resulting in an extraordinary fluorescence off-on response with a very low Limit of Detection(LOD)value.When Cu~(2+)was added to the compound BTPP,it displayed outstanding properties such as bright yellow emission,rapid reaction time(10 s),detection over a wide pH range(pH = 6-12),and reversibility with glutathione(GSH).FT-IR analysis,~1H NMR titration experiments,HRMS,and Job's plot analysis were used to determine the mechanism of BTPP's binding to Cu~(2+).Inspired by these remarkable sensing characteristics,we successfully used BTPP to detect Cu~(2+)in paper strip-based detection,ambient water samples,and fluorescent bio-imaging in E.coli bacteria with satisfying results.
Department of Chemistry,School of Advanced Sciences,Vellore Institute of Technology,Vellore,632014,India
Institute of Chemical Biology and Nanomedicine,State Key Laboratory of Chemo/Bio-sensing and Chemometrics,College of Chemistry and Chemical Engineering,Hunan University,Changsha,410082,PR China
NSTL
