首页|Two new ent-kaurane diterpenoids from the leaves of Sphagneticola trilobata
Two new ent-kaurane diterpenoids from the leaves of Sphagneticola trilobata
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NSTL
Elsevier
? 2022 Phytochemical Society of EuropeTwo new ent-kaurane diterpenoids, namely 3α,16α-dihydroxy-ent-kauran-19-oic acid (1) and 3α,9β-dihydroxy-ent-kauran-19-oic acid (2), together with eight known compounds were isolated and identified from the leaves of Sphagneticola trilobata. Their structures were elucidated on the basis of extensive spectroscopic analysis including 1D, 2D NMR and MS techniques. Known compounds 4, 5 and 8?10 were obtained from S. trilobata for the first time. These compounds were tested for their in vitro α-glucosidase inhibitory activity and their tyrosinase inhibitory potential. Compounds 2, 3 and 6 were found to show in vitro α-glucosidase inhibitory activity with IC50 values ranging from 0.398 to 0.476 mM, which were close or more potent than reference compound acarbose (IC50 0.410 mM). Compounds 2 and 6 were further revealed to show in vitro tyrosinase inhibitory activity (IC50 29.25 and 40.74 μM) but inferior to that of the positive control kojic acid (IC50 12.55 μM).
Liu S.-B.、Lou T.、Fu F.-Y.、Zhang S.-X.、Tan J.-W.、Ren H.、Xu Q.-L.
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State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources/Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm College of Forestry and Landscape Architecture South China Agricultural Un
Shaanxi Academy of Traditional Chinese Medicine
Guangdong Provincial Key Laboratory of Silviculture Protection and Utilization Guangdong Academy of Forestry
NSTL
Elsevier
