Small molecular theranostic agents play the pivot roles in the biomedical field and hold high clinical translational potential.However,it is still difficult to prepare these theranostic agents through a convenient and straightforward synthetic route.Herein,based on the electron-deficient building block boron difluoride formazanate(BDF),we designed and synthesized a novel NIR-II small molecular fluorescent dye(BDF-Ph)by flanking electron-rich triphenylamine units onto BDF to hamper the intermolecular π-π interaction,thus to achieve high fluorescence quantum yield.Then donor-acceptor-donor(D-A-D)structured BDF-Ph was encapsulated into amphiphilic polystyrene-g-poly(ethylene glycol)(PS-g-PEG)to prepare NIR-II fluorescent BDF-Ph NPs.BDF-Ph NPs possessed an emission peak at 975 nm with a high fluorescence quantum efficiency of 0.32%(IR1061,0 = 1.7%)and a high photothermal conversion efficiency of 40.1%,making it an excellent NIR-II fluorescent probe for nanotheranostics.In vivo investigation illustrated that BDF-Ph NPs exhibited strong NIR-II fluorescence signals.Meanwhile,upon exposure to 808 nm laser,BDF-Ph NPs could eradicate tumors without apparent adverse effects under the direction of NIR-II fluorescence imaging.These fascinating results confirmed that BDF-Ph NPs as an alternative theranostic nanoplatform could be used for oncotherapy.
NIR-II FluorescenceBoron difluoride formazanatePhotothermalIntramolecular charge transfer
Hui Lia、Hanming Dai、Anqing Mei
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Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM),School of Physical and Mathematical Sciences,Nanjing Tech University(NanjingTech),Nanjing,211816,China
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