首页|The influence of secondary interactions on the [Ni(O2)]+ mediated aldehyde oxidation reactions
The influence of secondary interactions on the [Ni(O2)]+ mediated aldehyde oxidation reactions
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NSTL
Elsevier
? 2021 Elsevier Inc.A rate enhancement of one to two orders of magnitude can be obtained in the aldehyde deformylation reactions by replacing the –N(CH3) groups of [NiIII(O2)(Me4[12]aneN4)]+ (Me4[12]aneN4 = 1,4,7,10-tetramethyl-1,4,7,10-tetraazacyclododecane) and [NiIII(O2)(Me4[13]aneN4)]+ (Me4[13]aneN4 = 1,4,7,10-tetramethyl-1,4,7,10-tetraazacyclotridecane) complexes by –NH in [NiIII(O2)([12]aneN4)]+ (2; [12]aneN4 = 1,4,7,10-tetraazacyclododecane) and [NiIII(O2)([13]aneN4)]+ (4; [13]aneN4 = 1,4,7,10-tetraazacyclotridecane). Based on detailed spectroscopic, reaction-kinetics and theoretical investigations, the higher reactivities of 2 and 4 are attributed to the changes in the secondary-sphere interactions between the [NiIII(O2)]+ and [12]aneN4 or [13]aneN4 moieties, which open up an alternative electrophilic pathway for the aldehyde oxidation reaction. Identification of primary kinetic isotope effects on the reactivity and stability of 2 when the –NH groups of the [12]aneN4 ligand are deuterated may also suggest the presence of secondary interaction between the –NH groups of [12]aneN4 and [NiIII(O2)]+ moieties, although, such interactions are not obvious in the DFT calculated optimized structure at the employed level of theory.
NSTL
Elsevier
