Rhamnose-based glycomimetic for recruitment of endogenous anti-rhamnose antibodies
Hribernik, Nives 1Chiodo, Fabrizio 2Pieters, Roland J. 3Bernardi, Anna1
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作者信息
1. Univ Milan
2. Vrije Univ Amsterdam
3. Univ Utrecht
折叠
Abstract
Recruitment of natural antibodies towards tumour cells for their elimination by the immune system could be a highly specific and efficacious therapeutic strategy. While natural L-rhamnose has already been explored as a suitable antigen for antibody recruitment, we here report the first rhamnose-based glycomimetic to be used for such purpose. The glycomimetic is designed to be more hydrolytically and enzymatically stable than natural rhamnosides, provides a site for easy further conjugation and proved to capture anti-rhamnose IgG antibodies in serological ELISA assay.(c) 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Key words
L -Rhamnose/Anti-carbohydrate antibodies/Glycomimetics/Immunotherapy/ALPHA-GALACTOSYL EPITOPES/ANTICARBOHYDRATE ANTIBODIES/AFFINITY/BINDING/BIOSYNTHESIS/CYTOTOXICITY/LIGANDS/DESIGN/CANCER/CELLS
NSTL
Elsevier