首页|Association study of polymorphisms within inflammatory genes and methylation status in treatment response in major depression

Association study of polymorphisms within inflammatory genes and methylation status in treatment response in major depression

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  • NSTL
  • Elsevier
Background: Although pharmacogenetics for major depressive disorder (MDD) is gaining momentum, the role of genetics in differences in response to antidepressant treatment is controversial, as they depend on multifactorial and polygenic phenotypes. Previous studies focused on the genes of the serotonergic system, leaving apart other pathological factors such as the inflammatory pathway. The main objective of the study was to assess whether treatment response might be associated with specific inflammation-related genetic variants or their methylation status.

Treatment responseMajor depressionInflammatory genesMethylation status

Gallego-Fabrega, Cristina、Jubero, Miriam、Carceller-Sindreu, Mar、Portella, Maria J.、Draganov, Metodi、Jesus Arranz, Maria、Salazar, Juliana、de Diego-Adelino, Javier

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Fundacio Docencia & Invest Mutua Terrassa, Res Lab, St Antoni 32, Barcelona 08221, Catalonia, Spain

Univ Autonoma Barcelona, Dept Psychiat, IIB St Pau, Hosp Santa Creu & St Pau,CIBERSAM, Barcelona

UAB, CIBER, IIB St Pau, Dept Genet,Hosp Santa Creu & St Pau, Barcelona, Spain

2019

10.1016/j.eurpsy.2019.05.003

European psychiatry :

European psychiatry :

ISSN：0924-9338
年,卷(期)：2019.60
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