首页|Insulin mimetic lanostane triterpenes from the cultivated mushroom Ganoderma orbiforme

Insulin mimetic lanostane triterpenes from the cultivated mushroom Ganoderma orbiforme

扫码查看
原文链接
  • NSTL
  • Elsevier
? 2022 Phytochemical Society of EuropeTwo new lanostane triterpenes, ganorbifoins A and B (1-2), together with the known compound (25S,3′S)-(+)-12α-hydroxy-3α-(3′-hydroxy-4′-methoxycarbonyl-3′-methylbutiryloxy)-24-methyllanosta-824-(31)-dien-26-oic acid (3) were isolated from the cultivated fruiting bodies of Ganoderma orbiforme. The structures of isolates were determined by extensive analysis of NMR and HRESIMS. All compounds induced glucose uptake in zebrafish-based system at the concentration of 10 μM. And the best performing compound is ganorbifoin A. Compounds 2 and 3 exhibited an inhibitory effect on nitric oxide production in LPS-induced BV-2 microglia cells at the concentration of 20 μM.

Ganoderma orbiformeGanodermataceaeInsulin mimeticsLanostane triterpenes

Yang A.-A.、Yan Y.-X.、Shi P.-D.、Yu C.、Feng Y.-Z.、Zhang M.-K.、Cao C.-Y.、Yin X.、Xing L.

展开 >

Shaanxi Key Laboratory of Natural Products & Chemical Biology College of Chemistry and Pharmacy Northwest A&F University

Key Laboratory of Regional Ecological Environment Analysis and Pollution Control of West Guangxi School of Chemistry and Environment Engineering Baise University

2022

10.1016/j.phytol.2022.01.003

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.48
  • 1
  • 16