首页|Chronic Remote Ischemic Conditioning Is Cerebroprotective and Induces Vascular Remodeling in a VCID Model
Chronic Remote Ischemic Conditioning Is Cerebroprotective and Induces Vascular Remodeling in a VCID Model
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NSTL
Springer Nature
Vascular contributions to cognitive impairment and dementia (VCID) make up 50% of the cases of dementia. The purpose of this study was to determine the effect of chronic remote ischemic conditioning (C-RIC) on improving long-term (6 months) outcomes and cerebral blood flow (CBF) and collateral formation in a mouse model of VCID. Adult C57BL/6J male mice (10 weeks) were randomly assigned to four different groups: (1) sham-bilateral carotid artery stenosis (BCAS), (2) BCAS + sham RIC, (3) BCAS+C-RIC for 1 month (1MO), and (4) BCAS+C-RIC-4 months (4MO). CBF, cognitive impairment, and functional outcomes were performed up for 6 months after BCAS surgery. The expression of CD31, alpha-SMA, and myelin basic protein (MBP) was assessed by immunohistochemistry (IHC). Additional set of mice were randomized to sham, BCAS, and BCAS+C-RIC. The cerebrovascular angioarchitecture was studied with micro-CT. RIC therapy for either 1 or 4 months significantly improved CBF, new collateral formation, functional and cognitive outcomes, and prevented white matter damage. There was no difference between C-RIC for 1 or 4 months; IHC studies at 6 months showed an increase in brain CD31 and alpha-SMA expression indicating increased angiogenesis and MBP indicating preservation of white matter in animals receiving RIC. One month of daily RIC is as effective as 4 months of daily RIC in improving CBF, angiogenesis, and long-term functional outcomes (6 months) in a VCID model. This suggests that 1 month of RIC is sufficient to reduce cognitive impairment and induce beneficial cerebrovascular remodeling.
Chronic remote ischemic conditioning (C-RIC)Cerebral blood flow (CBF)Vascular contributions to cognitive impairment and dementia (VCID)Angiogenesiscollateral remodelingwhite matter degeneration
Khan, Mohammad Badruzzaman、Hafez, Sherif、Hoda, Md. Nasrul、Baban, Babak、Wagner, Jesse、Awad, Mohamed E.、Sangabathula, Hasith、Haigh, Stephen、Elsalanty, Mohammed、Waller, Jennifer L.、Hess, David C.
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Augusta Univ, Med Coll Georgia, Dept Neurol, 1120 15th St,CA1053, Augusta, GA 30912 USA
Augusta Univ, Dept Med Lab Imagine & Radiol Sci, Augusta, GA 30912 USA
Augusta Univ, Dept Oral Biol, Augusta, GA 30912 USA
Augusta Univ, Vasc Biol Ctr, Augusta, GA 30912 USA
NSTL
Springer Nature
