首页|A method to avoid errors associated with the analysis of hypermutated viral sequences by alignment-based methods
A method to avoid errors associated with the analysis of hypermutated viral sequences by alignment-based methods
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NSTL
Elsevier
The human genome encodes for a family of editing enzymes known as APOBEC3 (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like3). They induce context dependent G-to-A changes, referred to as "hypermutation", in the genome of viruses such as HIV, SIV, HBV and endogenous retroviruses. Hypermutation is characterized by aligning affected sequences to a reference sequence. We show that indels (insertions/deletions) in the sequences lead to an incorrect assignment of APOBEC3 targeted and non-target sites. This can result in an incorrect identification of hypermutated sequences and erroneous biological inferences made based on hypermutation analysis. (C) 2015 Elsevier Inc. All rights reserved.
NSTL
Elsevier
