首页|Octreotide and melatonin alleviate inflammasome-induced pyroptosis through inhibition of TLR4-NF-kappa B-NLRP3 pathway in hepatic ischemia/reperfusion injury
Octreotide and melatonin alleviate inflammasome-induced pyroptosis through inhibition of TLR4-NF-kappa B-NLRP3 pathway in hepatic ischemia/reperfusion injury
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NSTL
Elsevier
Background and aim: The Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-kappa B)/NLRP3 inflammasome signaling pathway is essential in the pathogenesis of hepatic ischemia/ reperfusion (HIR) injury. Pyroptosis is a pminflammatory programmed cell death that is related to several diseases. Thus, the purpose of this study was to examine whether pretreatment with octreotide (somatostatin analogue, OCT) at different doses or OCT at 75 mu g/kg combined with melatonin (N-acetyl-5-methoxytryptamine, MLT) can alleviate HIR injury via targeting NLRP3 inflammasome-induced pyroptosis in a TLR4/MyD88/NF-kappa B dependent manner.
NSTL
Elsevier
