首页|Prediction of plasma profiles of a weakly basic drug after administration of omeprazole using PBPK modeling

Prediction of plasma profiles of a weakly basic drug after administration of omeprazole using PBPK modeling

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  • NSTL
  • Elsevier
Background: Oral medicines must release the drug appropriately in the GI tract in order to assure adequate and reproducible absorption. Disease states and co-administration of drugs may alter GI physiology and therefore the release profile of the drug. Acid-reducing agents (ARAs), especially proton pump inhibitors (PPIs), are frequently co-administered during various therapies. As orally administered drugs are frequently poorly soluble weak bases, PPI co-administration raises the risk of pH-induced drug-drug interactions (DDIs) and the potential for changes in the therapeutic outcome.

Weak baseDrug-drug interaction(s)Proton pump inhibitorAcid-reducing agentPhysiologically based pharmacokinetic (PBPK) modelingDissolutionpH

Segregur, Domagoj、Mann, James、Moir, Andrea、Karlsson, Eva M.、Dressman, Jennifer

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Goethe Univ Frankfurt, Inst Pharmaceut Technol, 9 Max von Laue St, D-60438 Frankfurt, Germany

AstraZeneca, Oral Prod Dev, Pharmaceut Technol & Dev, Operat, Macclesfield, Cheshire, England

AstraZeneca, New Modal & Parenteral Dev, Pharmaceut Technol & Dev, Operat, Macclesfield, Cheshire

AstraZeneca, Oral Prod Dev, Pharmaceut Technol & Dev, Operat, Gothenburg, Sweden

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2021

10.1016/j.ejps.2020.105656

European journal of pharmaceutical sciences

European journal of pharmaceutical sciences

ISTP
ISSN：0928-0987
年,卷(期)：2021.158
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