首页|Antiviral drugs targeting endosomal membrane proteins inhibit distant animal and human pathogenic viruses

Antiviral drugs targeting endosomal membrane proteins inhibit distant animal and human pathogenic viruses

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The endocytic pathway is a common strategy that several highly pathogenic viruses use to enter into the cell. To demonstrate the usefulness of this pathway as a common target for the development of broad-spectrum antivirals, the inhibitory effect of drug compounds targeting endosomal membrane proteins were investigated. This study entailed direct comparison of drug effectiveness against animal and human pathogenic viruses, namely Ebola (EBOV), African swine fever virus (ASFV), and the severe acute respiratory syndrome coronavirus 2 (SARSCoV-2).

SARS-CoV-2EBOVASFVAntiviralsPIKfyveCalcium channels

Galindo, I、Garaigorta, U.、Lasala, F.、Cuesta-Geijo, M. A.、Bueno, P.、Gil, C.、Delgado, R.、Gastaminza, P.、Alonso, C.

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Inst Nacl Invest & Tecnol Agr & Alimentaria INIA, Dept Biotechnol, Ctra Coruna Km 7-5, Madrid 28040

Ctr Nacl Biotecnol CSIC, Calle Darwin 3, Madrid 28049, Spain

Inst Invest Biomed Hosp, 12 Octubre S-N, Madrid 28041, Spain

Ctr Invest Biol Margarita Salas CSIC, Ramiro Maeztu 9, Madrid 28040, Spain

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2021

Antiviral research.

Antiviral research.

ISSN:0166-3542
年,卷(期):2021.186
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