首页|Antiviral drugs targeting endosomal membrane proteins inhibit distant animal and human pathogenic viruses
Antiviral drugs targeting endosomal membrane proteins inhibit distant animal and human pathogenic viruses
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NSTL
Elsevier
The endocytic pathway is a common strategy that several highly pathogenic viruses use to enter into the cell. To demonstrate the usefulness of this pathway as a common target for the development of broad-spectrum antivirals, the inhibitory effect of drug compounds targeting endosomal membrane proteins were investigated. This study entailed direct comparison of drug effectiveness against animal and human pathogenic viruses, namely Ebola (EBOV), African swine fever virus (ASFV), and the severe acute respiratory syndrome coronavirus 2 (SARSCoV-2).