Tetrahedron letters2022，Vol.954.DOI:10.1016/j.tetlet.2022.153731

De novo synthesis of polysubstituted 6-naphthylamines via Tf2O-mediated [4+2] annulation of amides with alkynes

Hu, Xiaoyan Hao, Shuanghong Wei, Yan Wang, Zu-Li Wang, Hongmei Feng, Yongcheng Qin, Qixue
Tetrahedron letters2022，Vol.954.DOI:10.1016/j.tetlet.2022.153731
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  • NSTL
  • Elsevier

De novo synthesis of polysubstituted 6-naphthylamines via Tf2O-mediated [4+2] annulation of amides with alkynes

Hu, Xiaoyan 1Hao, Shuanghong 1Wei, Yan 1Wang, Zu-Li 1Wang, Hongmei 1Feng, Yongcheng 1Qin, Qixue1
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作者信息

  • 1. Qingdao Agr Univ
  • 折叠

Abstract

A conceptually new strategy has been described for the mild and environmentally friendly preparation of 6-naphthylamines via Tf2O-activated cyclization of amides with alkynes. Both terminal and internal alkynes could serve as effective nucleophiles in this transformation. This chemistry features simple reaction conditions, high chemoselectivities, wide substrate scope, and offers a practical approach to polysubstituted 6-naphthylamines.(C) 2022 Elsevier Ltd. All rights reserved.

Key words

Amide activation/Alkynes/Cyclization/beta-Naphthylamines/De novo synthesis/DERIVATIVES/LIGANDS/ARYL/TRANSFORMATIONS/ALKENES

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出版年

2022
Tetrahedron letters

Tetrahedron letters

CCR
ISSN：0040-4039
参考文献量33
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