首页|Antifungal activity of volatile organic compounds (VOCs) produced by Streptomyces olivochromogenes S103 against Candida albicans
Antifungal activity of volatile organic compounds (VOCs) produced by Streptomyces olivochromogenes S103 against Candida albicans
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NSTL
Springer Nature
The genus Streptomyces remains a major source of novel pharmaceutically relevant compounds with antimicrobial activity. A screening method was carried out using ten strains of the genus Streptomyces, isolated from Tunisian soil (Ain Drahem), against Candida albicans pathogenic yeast. The antifungal activity of volatile compounds (VOCs) of Streptomyces isolates was released with the double dish method and the separate compartments dish method. This screening allowed us to select strain S103, which showed the highest inhibition rate against Candida albicans up to 65%. This strain was identified as Streptomyces olivochromogenes on the basis of its morphological characteristics, and 16S rRNA gene sequence analysis. After 14 days of incubation, solid-phase microextraction followed by gas chromatography-mass spectrometry (SPME-GC-MS) identified 15 volatile organic compounds produced by this strain. Among these, the most abundant volatile substance was D-limonene, with 55.81% of total peaks. Bioassay with standard D-limonene showed that 200 mu l per plate completely inhibited C. albicans growth by fumigation. Hence, microbial VOCs may be a new therapeutic alternative to combat the high incidence of Candida infections.
NSTL
Springer Nature
