首页|Two new alkaloids from Pachysandra terminalis and their antibacterial activity assessment

Two new alkaloids from Pachysandra terminalis and their antibacterial activity assessment

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  • NSTL
  • Elsevier
? 2022 Phytochemical Society of EuropePhytochemical investigation of a 90 % ethanol extract of Pachysandra terminalis Sieb. Et Zucc led to the isolation of a novel alkaloid, terminamine T (1); a new pregnane-type alkaloid, terminamine U (2); and four known pregnane-type alkaloids (3-6). The structures of these compounds were elucidated on the basis of nuclear magnetic resonance spectra, mass spectrometry data, single-crystal X-ray diffraction, and by a comparison with data from the literature. All compounds were evaluated for their antibacterial activities against gram-positive (S. aureus, ATCC 29213) and gram-negative (E. coli, ATCC 25922) bacteria. Compounds 2-6 exhibited generally modest to poor antibiotic properties. Furthermore, compound 2 showed antibacterial activity against methicillin-resistant Staphylococcus epidermidis (MRSE), methicillin-resistant Staphylococcus aureus (MRSA), and methicillin-resistant Staphylococcus aureus USA300 (LAC) with a minimal inhibitory concentration (MIC) value of 32 μg/mL (75 μM) and minimum bactericidal concentration (MBC) values of 64, 128, and 128 μg/mL (150, 300, and 300 μM), respectively.

AlkaloidsAntibacterial activityPachysandra terminalisPregnane-type alkaloids

Wang X.-Y.、Ma X.、Liu J.-T.、Ning H.、Zhang Y.-H.、Gao H.、Ma Z.-C.、Wang G.-Y.、Huangfu L.-T.、Tang H.-F.

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Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Pharmacy Peking University Cancer Hospital & Institute

Department of Stomatology the Eighth Medical Center Chinese PLA General Hospital

Department of Pharmacy Beijing Tiantan Hospital affiliated to Capital Medical University

Department of Pharmacy Tianjin Medical University Cancer Institute & Hospital

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Division of Gastrointestinal Cancer Translational Research Laboratory Peking University Cancer Hospital & Institute

Department of Chinese Materia Medica and Natural Medicines School of Pharmacy The Air Force Medical University

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2022

10.1016/j.phytol.2022.01.014

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.48
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