首页|Stability study of a compounded oral solution of nicardipine for the treatment of hypertension in children

Stability study of a compounded oral solution of nicardipine for the treatment of hypertension in children

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  • NSTL
  • Elsevier
Nicardipine is an antihypertensive drug that may be used off-label by oral route to treat hypertension in children. Currently commercially available tablets are inappropriate for oral use in children and manufactured hard capsules are not suitable for easy dose individualization to achieve target blood pressure. We aimed to fulfill this lack of appropriate dose forms by developing an oral liquid formulation of nicardipine.

NicardipineOralPediatricsHypertensionStability studyHPLC-MSMS

Fuss, Damien、Gonde, Henri、Lamoureux, Fabien、Pereira, Tony、Colnot, Marion、Buchbinder, Nimrod、Coquard, Aude、Varin, Remi、Hervouet, Charles

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Rouen Univ Hosp, Dept Pharm, 1 Rue Germont, F-76000 Rouen, France

Normandie Univ, Rouen Univ Hosp, Dept Pharm, U1234,UNIROUEN, F-76000 Rouen, France

Rouen Univ Hosp, Dept Pharmacol, F-76000 Rouen, France

Rouen Univ Hosp, Dept Pediat Oncol & Hematol, F-76000 Rouen, France

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2021

10.1016/j.ejps.2021.105738

European journal of pharmaceutical sciences

European journal of pharmaceutical sciences

ISTP
ISSN：0928-0987
年,卷(期)：2021.160
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