首页|Localized surface plasmon resonance biosensor designed for high refractive index volatile organic compound (VOC) biomarkers detection in visible spectrum
Localized surface plasmon resonance biosensor designed for high refractive index volatile organic compound (VOC) biomarkers detection in visible spectrum
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NSTL
Elsevier
One of the most promising methods for early detection of certain cancers, infections, metabolic disorders, and some other diseases is the analysis of specified volatile organic compounds (VOC) biomarkers present in patients' bio-fluids and exhaled breath. Biosensors based on Localized surface plasmon resonance (LSPR) have the potential of real time detection of a monolayer of diagnostic biomarkers. This paper presents a wavelength-interrogated plasmonic biosensor with tunable sensitivity and selectivity performance toward VOC biomarkers detection. With the purpose of improving the dynamic detection range of the biomarker refractive indices (RI) in visible wavelengths, the effect of the thickness and configuration of the gold layer is studied. The performance of the designed biosensor is investigated by finite element method via COMSOL Multiphysics for various biomarkers. The numerical results show that the sensor based on the continuous metallic thin films patterned with periodic shallow cavities could be calibrated for several biomarkers with RI ranging from 1.329 to 1.436 in visible spectrum.
NSTL
Elsevier
