首页|THE ANTI-PHOTOAGING ACTIVITY OF DEEP SEA WATER ON HACAT KERATINOCYTE INDUCED BY UVB VIA SUPPRESSION MMPS AND MAPKS/NF-KB SIGNALING PATHWAY
THE ANTI-PHOTOAGING ACTIVITY OF DEEP SEA WATER ON HACAT KERATINOCYTE INDUCED BY UVB VIA SUPPRESSION MMPS AND MAPKS/NF-KB SIGNALING PATHWAY
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NSTL
Polskie Towarzystwo Farmaceutyczne
Ultraviolet radiation may cause oxidative stress, inflammation, collagen degradation, and other skin damage. In this study, the photoaging model of the human immortal keratinocyte line (HaCaT) was established by UV irradiation, and the expression of cytokines and MAPK pathway proteins was studied to evaluate the protective effect of DSW on UVB-induced cell photoaging. The results of oxidase system detection showed that DSW could significantly up-regulate the UVB-induced overexpression of superoxide dismutase (SOD)M, Catalase, and glutathione peroxidase (GSH-Px), meanwhile, the content of malondialdehyde was down-regulated. Cytokine expression detection results showed that DSW significantly reduced the expression levels of pro-inflammatory cytokines (TNF-alpha, IL-6). Western blot results showed that DSW significantly down-regulated UVB-induced overexpression of MMPs protein significantly reduced the phosphorylation level of MAPKs pathway proteins (SAPK/JNK, ERK1/2, p38 MAPK), and weakened the nuclear transposition expression of kappa-B induced by UVB. In conclusion, DSW significantly alleviates inflammatory response and oxidative stress damage in UVB-induced model HaCaT cells, and DSW can be used as potentially effective skin care and application material to reduce UVB-induced skin inflammation.
NSTL
Polskie Towarzystwo Farmaceutyczne
