首页|Ferroptosis plays an essential role in the antimalarial mechanism of low-dose dihydroartemisinin
Ferroptosis plays an essential role in the antimalarial mechanism of low-dose dihydroartemisinin
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The activation of artemisinin and its derivatives (ARTs) to generate ROS and other free radicals is mainly heme-or ferrous iron-dependent. ARTs induce ferroptosis in tumor cells, although the involvement of ferroptosis in malaria remains unclear. We found that three typical inducers of ferroptosis (erastin, RSL3 and sorafenib) could effectively mimic DHA inhibition on the growth of blood-stage parasites, which exhibited synergistic or nearly additive interactions in vitro with DHA, while the combination of DHA with ferroptosis inhibitors (deferoxamine, liproxstatin-1) had an obvious antagonistic effect. DHA, similar to ferroptosis inducers, can simultaneously induce the accumulation of ferroptosis-associated cellular labile iron and lipid peroxide. However, deferoxamine and liproxstatin-1 reduced the increase in ferrous iron and lipid peroxide caused by DHA. These results suggested that ferroptosis might be an effective way to induce cell death in parasites and could be a primary mechanism by which DHA kills parasites, with almost 50% contribution at low concentrations. These results provide a new strategy for antimalarial drug screening and clinical medication guidance.
MalariaFerroptosisDihydroartemisininAnti-malarial drug combinations
Ji Ma、Tingliang Jiang、Canghai Li、Shuo Li、Wenhui Xu、Huajing Wang、Tian Tang、Zhao Cui、Hang Shi、Ting Qin、Hongying Zhou、Lanfang Li
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Research Center of Artemisinin, China Academy of Chinese Medical Sciences, Beijing 100700, China
NSTL
