首页|Sesquiterpenoids and their glycosides from Dobinea delavayi (Baill.) Baill

Sesquiterpenoids and their glycosides from Dobinea delavayi (Baill.) Baill

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  • NSTL
  • Elsevier
Eight undescribed sesquiterpenoids, including two eudesmane glycosides dobinosides A and B, five eudesmane aglycones dobinins Q-U, and one germacrane dobinin P, were isolated from the 80% ethanol extract of roots of Dobinea delavayi. Their structures were elucidated by extensive spectroscopic data (1D and 2D NMR, HR-ESI-MS) and single-crystal X-ray diffraction analysis. Dobinoside A, dobinins Q and R, as well as six reported eudesmane sesquiterpenoids, were evaluated for their in vivo antimalarial activities against Plasmodium yoelii BY265RFP in mice. A summary of preliminary structure-activity relationship of eudesmane sesquiterpenoids for in vivo antimalarial activity was described.

Dobinea delavayiAnacardiaceaeEudesmane sesquiterpenoid glycosidesEudesmane sesquiterpenoidsGermacrene sesquiterpenoidAntimalarial activityStructure-activity relationship

Wu, Xiu-Rong、Shen, Yi、Diao, Hong-Mei、Dong, Xiang、Xiao, Chao-Jiang、Jiang, Bei

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Yunnan Key Lab Screening & Res Antipathogen Plant

Dali Univ

2022

10.1016/j.phytochem.2021.112999

Phytochemistry

Phytochemistry

CCR
ISSN：0031-9422
年,卷(期)：2022.193
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