Tetrahedron letters2022，Vol.1004.DOI:10.1016/j.tetlet.2022.153902

Tandem defluorination/annulation of alpha-CF3 carbonyls with bis-nucleophiles: Stereodivergent synthesis of 2-alkylidene-1,3-heterocycles

Ma, Yangyang Mao, Kuantao Chen, Yuanjin Lv, Leiyang Li, Zhiping
Tetrahedron letters2022，Vol.1004.DOI:10.1016/j.tetlet.2022.153902
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  • NSTL
  • Elsevier

Tandem defluorination/annulation of alpha-CF3 carbonyls with bis-nucleophiles: Stereodivergent synthesis of 2-alkylidene-1,3-heterocycles

Ma, Yangyang 1Mao, Kuantao 1Chen, Yuanjin 2Lv, Leiyang 1Li, Zhiping1
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作者信息

  • 1. Renmin Univ China
  • 2. Peking Univ
  • 折叠

Abstract

A practical protocol for the stereodivergent synthesis of 2-alkylidene-1,3-N,X-heterocycles (X = O, S, NR) from the reactions of alpha-CF3 carbonyls and bis-nucleophiles has been developed under metal-free and ambient conditions. The reaction proceeds via the tandem defluorination of alpha-CF3 carbonyls followed by sequential nucleophilic substitution with two heteroatoms of bis-nucleophiles in a stereodivergent manner. (C) 2022 Elsevier Ltd. All rights reserved.

Key words

alpha-CF3 carbonyls/Tandem defluorination/Annulation/Stereodivergent/2-Alkylidene-1/3-oxazolidines/TRIFLUOROMETHYLATION/FLUORINATION/GENERATION/CHEMISTRY/ENOLATE

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出版年

2022
Tetrahedron letters

Tetrahedron letters

CCR
ISSN：0040-4039
被引量3
参考文献量48
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