首页|Lignanamides from the stems of Piper hancei maxim. and their anti-inflammatory and cytotoxic activities

Lignanamides from the stems of Piper hancei maxim. and their anti-inflammatory and cytotoxic activities

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  • NSTL
  • Elsevier
? 2022 Elsevier B.V.Four new lignanamides, hancamides A ? D (1–4), together with four known analogs (5–8), were isolated from the stems of Piper hancei Maxim. Their structures were determined based on 1D and 2D NMR, IR, UV, and HR-ESIMS spectroscopic analysis as well as by comparison with the reported data. All the isolates exhibited potential inhibitory effects on NO production in LPS-induced BV-2 microglial cells, with IC50 values of 4.26–40.68 μM. Moreover, compounds 2 and 8 displayed moderate cytotoxic activities against MGC-803, HepG2, SKOV-3, T24, and HeLa cells, with IC50 values ranging from 13.57 to 34.20 μM, respectively.

Anti-inflammationCytotoxicityLignanamidesPiper hancei maxim.Piperaceae

Yang F.、Li H.、Liang D.、Yang Y.-Q.、Hou Y.

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State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Collaborative Innovation Center for Guangxi Ethnic Medicine School of Chemistry and Pharmaceutical Sciences Guangxi Normal University

College of Life and Health Sciences Northeastern University

2022

10.1016/j.fitote.2022.105231

Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
年,卷(期)：2022.161
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