首页|A strategy to distinguish cancers from normal cells through lysosomal targeted double site fluorescent probe for lipase and hydrogen sulfide
A strategy to distinguish cancers from normal cells through lysosomal targeted double site fluorescent probe for lipase and hydrogen sulfide
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NSTL
For tumor resection,the key step is to distinguish normal from tumor cells accurately.In this article,a lysosome targeting double site fluorescent probe T was reported for porcine pancreatic lipase(PPL)and hydrogen sulfide(H2S).In PBS solution,T could be hydrolyzed by PPL and emitted yellow fluorescence,but no fluorescence change could be observed by H2S only.While in the coexistence of PPL and H2S,a double site chemical reaction was activated,and blue fluorescence was found in the end.The concentration of H2S in some cancer cells is high enough to trigger this dual-site chemical reaction for T.This phenomenon can be repeated in cell experiments:T emits yellow fluorescence in normal cells(MPC)and blue fluorescence in cancer cells(HeLa and SMCC-7721).It illuminates a fact that a vast amount of H2S existed in these cancer cells.As a result,probe T could be used to distinguish cancer cells from normal cells with different fluorescence colors.
NSTL
